What Is Rejuran? A Complete Guide to Salmon-DNA Skin Booster Benefits, Types, and Treatment Intervals (2026)

as an injectable skin booster that improves the skin’s own regenerative environment.

its key distinction is that it addresses tissue recovery and the environment for collagen production.

A typical cycle consists of 3–4 sessions at 2–4-week intervals. Raised injection-site bumps and redness may remain for about 1–3 days

after treatment. It is primarily considered when skin retains firmness but texture and recovery are diminished, such as concerns involving pores, fine lines, texture, or thin eye-area skin. If sagging is the main concern, combining it with lifting devices such as Ultherapy or Thermage is a reasonable approach.

Responses vary considerably with individual skin condition and accompanying procedures, so an in-person medical consultation is essential before treatment.

These questions recur in clinic visits and online consultations. This article answers them in order.

• What exactly is Rejuran, and how does it differ from fillers or hydration injections?

• How do Rejuran Healer, HB, HB+, and Eye differ?

• How many sessions are needed, and how long do results last?

• How many days of downtime are there? Can I work the next day?

• Should I start with Rejuran, Juvelook, or Sculptra?

• Can I receive it on the same day as Ultherapy, Thermage, or InMode?

Rejuran is a brand of PN-based injectables developed by Korean pharmaceutical company PharmaResearch. Its main ingredient is polynucleotides, made by purifying DNA extracted from salmon testes into lower-molecular-weight material. In Korea, it is approved for use as a biomaterial for tissue repair.

Its mechanism differs from other injectable treatments.

• Fillers physically replenish hollow areas with hyaluronic acid.

• Hydration injections deliver moisture to superficial skin layers for immediate hydration and radiance.

• Rejuran delivers PN to the dermis, focusing on an environment favorable to fibroblast activity. Rather than an immediately visible change, texture and perceived skin thickness improve over repeated sessions.

Rejuran is therefore closer to ‘managing your skin’s condition months from now’ than ‘looking beautiful today.’

One of the most common misconceptions is judging its effectiveness after only one session.

▪ Rejuran Healer

▪ Rejuran HB

▪ Rejuran HB+

▪ Rejuran Eye

※ Formulation choice depends on skin thickness, oil–water balance, and plans for accompanying procedures. Individual prescriptions may differ.

Downtime typically involves small raised injection-site bumps that settle the same day or within three days. The thin skin around the eyes may bruise. Schedule treatment at least 5–7 days before an important event. Avoid saunas, vigorous exercise, and alcohol for 24 hours, and take care with sun protection and hydration.

▪ Rejuran

▪ Juvelook

▪ Sculptra

▪ Hydration Injections

In one sentence: Rejuran for thin skin that recovers poorly; Sculptra or Juvelook for hollowness and volume loss; hydration injections for immediate dryness and roughness. In practice, treatments are more often combined at different times than limited to a single choice.

Skin is layered, and each treatment addresses different layers. Understanding this structure makes the combinations clearer.

• Ultherapy — Ultrasound lifting reaching the SMAS layer, for concerns primarily involving sagging.

• Thermage — Radiofrequency treatment for firmness throughout the dermis, lax texture, and the jawline.

• InMode — Radiofrequency-based treatment used to address swelling and refine contours.

• Rejuran — Supports the dermal regenerative environment, underpinning results from the devices above.

A common sequence is to establish structure with lifting devices, then improve texture with Rejuran. Whether treatments can be performed on the same day depends on skin response and downtime and should be discussed during consultation.

Developed by a Korean company, Rejuran has the longest and broadest accumulated clinical experience in Korea.

• Treatment in its country of origin — The market where new formulations are introduced first.

• Gangnam’s concentration of clinics — Clinics clustered around Gangnam Station and Yeoksam-dong make treatment and return visits convenient.

• Fits a short itinerary — One session takes about an hour, including waiting time.

• Registration for treating international patients — A formal system allows international patients to receive care through medical institutions registered with the Ministry of Health and Welfare.

Incheon Airport to Gangnam Station takes approximately 70–90 minutes by airport bus or airport railway plus subway.

A typical cycle consists of 3–4 sessions at 2–4-week intervals.

Many then switch to maintenance every 3–6 months.

Texture improvements generally last several months, but vary considerably with age, lifestyle, and UV exposure.

To maintain results longer, SEOLREIM recommends combination treatment with lifting or other injections rather than Rejuran alone.

Raised injection marks and redness may remain after Rejuran, so treatment is recommended 5–7 days before an important event.

If considering Rejuran during a trip to Korea, we recommend scheduling it on your final day before departure.

Injection-site pain, swelling, bruising, and temporary raised bumps are commonly reported.

Inflammatory reactions may occur rarely. Every medical procedure carries risks, so obtain a full explanation before deciding.

Since opening in 2011, SEOLREIM CLINIC has provided dermatologic and aesthetic care near Gangnam Station in Seoul for 16 years.

Rather than routinely using Rejuran alone, we assess skin thickness and sagging together and plan its sequence with lifting and pigmentation care.

alongside lifting devices including Ultherapy, Thermage FLX, Oligio, and ONDA.

Hours: Mon/Wed/Thu 10:00–19:00 / Tue/Fri 11:00–20:00 / Sat 10:00–16:00 / Closed Sundays and public holidays

This content provides general medical information about Rejuran and does not replace diagnosis or treatment for an individual patient.

Treatment effects, responses, and recovery periods vary, and all medical procedures carry a possibility of side effects. Decide whether to proceed through an in-person consultation with a medical professional.